2,6-Dimethylphenylboronic acid → {(S)-6-[(R)-7-Fluoro-4-(2-(2,6-dimethyl-phenyl)-pyridin-3-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	2,6-Dimethylphenylboronic acid	HCID 583322	—
Reactant	{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester	HCID 86697103	—
Reactant	{(S)-6-[(R)-4-(2-Bromo-pyridin-3-yl)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester	HCID 86697291	—
Product	{(S)-6-[(R)-7-Fluoro-4-(2-(2,6-dimethyl-phenyl)-pyridin-3-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester	HCID 86697325	—

Reaction Steps

The title compound is prepared from {(S)-6-[(R)-4-(2-bromo-pyridin-3-yl)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2,6-dimethyl-phenylboronic acid following a procedure analogous to that described in Step 5 of Intermediate 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08642585B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-52824046084f4426bf013710700b871c
Source note	uspto-grants-2014_02