Ethyl acetate hexane → Ethyl 3-(4-(5-((3,3-dimethylbutanoyl)amino)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-3-yl)phenyl)propanoate

HRID 2376523Notes

Reaction equation

HRID 2376523 reaction equation
[CH3:1][C:2]([CH3:31])([CH3:30])[CH2:3][C:4]([NH:6][C:7]1[C:8]([CH3:29])=[C:9]([CH3:28])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([O-:25])=[O:24])=[CH:17][CH:16]=3)[C:11]=2[C:26]=1[CH3:27])=[O:5].[C:32](OCC)(=O)[CH3:33].CCCCCC>>[CH3:1][C:2]([CH3:31])([CH3:30])[CH2:3][C:4]([NH:6][C:7]1[C:8]([CH3:29])=[C:9]([CH3:28])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][C:23]([O:25][CH2:32][CH3:33])=[O:24])=[CH:17][CH:16]=3)[C:11]=2[C:26]=1[CH3:27])=[O:5]

Participants

3

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 23114328(2E)-3-(4-(5-((3,3-dimethylbutanoyl)amino)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-3-yl)phenyl)acrylate

Product 1

HCID 23113956Ethyl 3-(4-(5-((3,3-dimethylbutanoyl)amino)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-3-yl)phenyl)propanoateYield 84%

Procedure

Using (2E)-3-(4-(5-((3,3-dimethylbutanoyl)amino)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-3-yl)phenyl)acrylate obtained in Example 178, the title compound was synthesized in the same manner as in Example 180. Yield: 84%. Melting point: 103-105° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-f022c71e19e7487fab4be47225fae03c
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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