Acetyl chloride → HCID 23114040, compound

HRID 2376535Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[C:15]([CH3:23])=[C:16]([NH:20][CH:21]=[O:22])[C:17]([CH3:19])=[CH:18][C:13]=3[O:12][CH2:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:24](Cl)(=[O:26])[CH3:25]>>[C:24]([C:18]1[C:13]2[O:12][CH2:11][CH:10]([C:7]3[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=3)[C:14]=2[C:15]([CH3:23])=[C:16]([NH:20][CH:21]=[O:22])[C:17]=1[CH3:19])(=[O:26])[CH3:25]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 23114243HCID 23114243, compound

Product 1

HCID 23114040HCID 23114040, compoundYield 48%

Procedure

Using N-(3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)formamide obtained in Example 58 and acetyl chloride, the title compound was obtained in the same manner as in Example 38. Yield: 48%. Melting point: 177-179° C. (ethyl acetate-hexane).

Sources & evidence

ORD record: ord-aada537f97984074ac32bc101d0dcd09
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07465815B2

Reaction notes

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