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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237659Generated: October 30, 2026

{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → HCID 86697332, compound

https://huagongshe.com/reaction/237659

Reaction equation

Participants

RoleNameHCIDCharge
Reactant{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697103—
Reactant{(S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697106—
ReactantHCID 86697331HCID 86697331—
ProductHCID 86697332HCID 86697332—

Reaction Steps

The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 5-(4-chloro-3,5-dimethyl-phenyl)-3-methyl-pyridazine following a procedure analogous to that described in Step 5 of Intermediate 1. LC (method 11): tR=1.09 min; Mass spectrum (ESI+): m/z=539 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08642585B2
Source datasetuspto-grants-2014_02
ORD IDord-1d4ada51dfc94460824258772071d877
Source noteuspto-grants-2014_02