HCID 23113844, compound → HCID 23114100, compound

HRID 2376593Notes

Reaction equation

HRID 2376593 reaction equation
[CH:1]([C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[C:6]([CH3:14])=[C:5]([NH:15][C:16](=[O:22])[CH2:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:4]=1[CH3:23])=[O:2].[C:24]1([Mg]Br)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[OH:2][CH:1]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:3]1[C:11]2[O:10][C:9]([CH3:12])([CH3:13])[CH2:8][C:7]=2[C:6]([CH3:14])=[C:5]([NH:15][C:16](=[O:22])[CH2:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:4]=1[CH3:23]

Participants

3

Reactant 2

HCID 23113844HCID 23113844, compoundHCID 178418255HCID 178418255, compound

Product 1

HCID 23114100HCID 23114100, compound

Procedure

Using N-(7-formyl-2,2,4,6-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethyl-butanamide obtained in Example 340 and phenylmagnesium bromide, the title compound was synthesized in the same manner as in Example 239. The yield was quantitative. Amorphous substance.

Sources & evidence

ORD record
ord-d6ddacb930f24cfa8189e0d8c600822a
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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