HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2376628Generated: October 31, 2026
Potassium Carbonate → HCID 68868568, compound
https://huagongshe.com/reaction/2376628
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | 8-Bromo-1,7-naphthyridin-6-amine | HCID 10704335 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68868568 | HCID 68868568 | — |
Reaction Steps
To a stirred solution of 6-amino-8-bromo-1,7-naphthyridine (0.5 g) in a mixture of toluene (2.5 ml), DMF (4 ml) and aqueous K2CO3 (0.68 g in 2 ml water) is added bis(dibenzylideneacetone)palladium (51 mg), triphenylphosphine (47 mg) and 3-fluorphenylboronic acid (0.33 g). The mixture is stirred for 4 hours at 100° C. The mixture is diluted with ethyl acetate, then filtered through a Celite™ filter. The ethyl acetate solution is washed with 2 N NaOH and water, dried over magnesium sulphate, then concentrated to afford the title compound. MS: APCI 240.0 MH+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07468370B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-1b6b28c25dde457cbbe374a323f649e8 |
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| Source note | uspto-grants-2008_12 |
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