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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237663Generated: October 29, 2026

{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → HCID 86697336, compound

https://huagongshe.com/reaction/237663

Reaction equation

Participants

RoleNameHCIDCharge
Reactant{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697103—
Reactant{(S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697106—
Reactant2-(4-Bromo-3,5-dimethyl-phenyl)-thiazoleHCID 86697335—
ProductHCID 86697336HCID 86697336—

Reaction Steps

The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2-(4-bromo-3,5-dimethyl-phenyl)-thiazole following a procedure analogous to that described in Step 5 of Intermediate 1. LC (method 7): tR=1.29 min; Mass spectrum (ESI+): m/z=530 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08642585B2
Source datasetuspto-grants-2014_02
ORD IDord-52377922d20f4c3f874d3476f31be7c2
Source noteuspto-grants-2014_02