HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2376630Generated: October 31, 2026
Potassium Carbonate → HCID 69461972, compound
https://huagongshe.com/reaction/2376630
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| Reactant | 8-Bromo-1,7-naphthyridin-6-amine | HCID 10704335 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 69461972 | HCID 69461972 | — |
Reaction Steps
To a stirred solution of 8-bromo-[1,7]naphthyridin-6-ylamine (1.70 g) in a mixture of toluene (7 ml), DMF (11 ml) and aqueous K2CO3 (2.31 g in 5 ml water) is added bis(dibenzylideneacetone)palladium (174 mg), triphenylphosphine (158 mg) and 5-fluoro-2-methoxyphenylboronic acid (1.38 g). The mixture is stirred for 3.5 hours at 100° C., then diluted with ethyl acetate and filtered through Celite. The ethyl acetate solution is washed with 2N NaOH and water, dried over magnesium sulphate, then concentrated to afford the title compound. MS: APCI 270.0 MH+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07468370B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-1dd204252bcb41c09d9f43e23480c1fa |
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| Source note | uspto-grants-2008_12 |
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