Hydrochloric Acid → HCID 10474424, compound

Participants

Reaction Conditions

Reaction Steps

{1-[8-(3-Cyano-phenyl)-[1,7]naphthyridin-6-yl]-piperidin-4-yl}-acetic acid ethyl ester (250 mg, 0.62 mmol) is dissolved in ethanol (5 ml) with 2M KOH (aq., 0.95 ml, 1.86 mmol) and the mixture stirred at 45° C. for 0.5 hours. After cooling, the pH of the mixture is adjusted to pH 3 by the dropwise addition of concentrated HCl. After stirring for 0.5 hours, the resultant solid is filtered and washed with water to yield the desired product. M.p. 178-180° C.

Provenance & Evidence