Hydrochloric Acid → HCID 23106772, compound

Participants

Reaction Steps

Ethyl (4-acetyl-2-{[(allyloxy)carbonyl]amino}phenyl)acetate (17.6 g) prepared by step e) and step f) was dissolved in ethanol (176 mL) and thereto was added at 0° C. 1M aqueous NaOH solution (132 mL), followed by stirring for 1 hour. To the reaction solution was added 2M hydrochloric acid (400 mL), and ethanol was removed in vacuo. The resulting solid was collected by filtration and washed with 2M hydrochloric acid, and dried in vacuo to give the object compound as a pale brown solid (11.2 g, 70%). Further the aqueous layer was extracted with ethyl acetate, dried over magnesium sulfate, filtered, and the solvent was removed in vacuo to give the object compound (3.58 g, 22%) as a brown solid.

Provenance & Evidence