1-methyl-1H-pyrazole-3-carboxylic acid → HCID 10194947, compound

HRID 2376697Notes

Reaction equation

HRID 2376697 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[N:3]1.Cl.Cl.[F:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[F:23])[N:19]=[C:18]([NH:24][CH2:25][CH2:26][NH:27][CH3:28])[CH:17]=[N:16]2>>[F:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[F:23])[N:19]=[C:18]([NH:24][CH2:25][CH2:26][N:27]([CH3:28])[C:7]([C:4]1[C:5]([C:20]3[CH:15]=[CH:14][C:13]([F:12])=[CH:22][CH:21]=3)=[CH:6][N:2]([CH3:1])[N:3]=1)=[O:9])[CH:17]=[N:16]2

Participants

3

Reactant 2

HCID 5731761-methyl-1H-pyrazole-3-carboxylic acidHCID 69145081HCID 69145081, compound

Product 1

HCID 10194947HCID 10194947, compound

Procedure

The title compound was prepared from 4-4-fluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid (46 mg, 0.21 mmol) and N-(6,7-difluoro-quinoxalin-2-yl)-N′-methyl-ethane-1,2-diamine.dihydrochloride, D2 (65 mg, 0.21 mmol) according to the procedure described for Example 1, as a yellow solid (65 mg, 71%).

Sources & evidence

ORD record
ord-24b6be8dd1d64c4eaf3cb9da4bfe2b9f
Source dataset
uspto-grants-2008_12
Patent number
US07468367B2

Reaction notes

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