HCID 21366116, compound → HCID 10238450, compound

HRID 2376700Notes

Reaction equation

HRID 2376700 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14]([OH:16])=O)=[CH:4][CH:3]=1.[Br:17][C:18]1[CH:19]=[N:20][C:21]([NH:24][CH2:25][CH2:26][NH:27][CH3:28])=[N:22][CH:23]=1>>[Br:17][C:18]1[CH:23]=[N:22][C:21]([NH:24][CH2:25][CH2:26][N:27]([CH3:28])[C:14]([C:9]2[N:10]=[C:11]([CH3:13])[S:12][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[O:16])=[N:20][CH:19]=1

Participants

3

Reactant 2

HCID 21366116HCID 21366116, compoundHCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid

Product 1

HCID 10238450HCID 10238450, compound

Procedure

The title compound was prepared from 5-(4-fluoro-phenyl)-2-methyl-thiazole-4carboxylic acid (78 mg, 0.33 mmol) and N-(5-bromo-pyrimidin-2-yl)-N′-methyl-ethane-1,2-diamine, D11 (76 mg, 0.33 mmol), according to the procedure described for Example 1, as a solid (105 mg, 71%).

Sources & evidence

ORD record
ord-c9aec98515ab43ddac807d496e1bc91c
Source dataset
uspto-grants-2008_12
Patent number
US07468367B2

Reaction notes

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