Benzoyl chloride → 1-Phenyl-2-(4-pyridyl)vinyl benzoate

HRID 2376714Notes

Reaction equation

[C:1]1([C:7](=[O:15])[CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16](Cl)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:16]([O:15][C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[CH:8][C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 2871041-Phenyl-2-(4-pyridinyl)ethanone

Product 1

HCID 684443451-Phenyl-2-(4-pyridyl)vinyl benzoateYield 62%

Procedure

Following a similar procedure to that described in reference example 4, but using 1-phenyl-2-(4-pyridyl)ethanone (obtained in reference example 3) instead of 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone and benzoyl chloride instead of 4-fluorobenzoyl chloride, the title compound was obtained (yield: 62%).

Sources & evidence

ORD record: ord-28f6de8e21154a0ab9fe79946fa33094
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07468376B2

Reaction notes

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