HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl isocyanate → HCID 68445793, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl isocyanate | HCID 61277 | — |
| Reactant | 2-(2-Aminoethyl)-4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine | HCID 67013573 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68445793 | HCID 68445793 | 50% |
Reaction Steps
To a solution of 2-(2-aminoethyl)-4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine (0.06 g, 0.15 mmol, obtained in example 90) in DMF (1 mL), isopropylisocyanate (0.02 g, 0.18 mmol) was added under argon atmosphere. This was stirred at room temperature for 2 days. The solvent was concentrated again and diethyl ether was added to the residue obtained. The solvent was concentrated, to afford 38 mg of title compound in solid form (yield: 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468376B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-5c59ac55329d464b82edacdf4f22a20d |
| Source note | uspto-grants-2008_12 |