2-(3-Bromopropoxy)tetrahydro-2H-pyran → 5-(2-Methylsulfanylpyrimidin-4-yl)-2-[3-(tetrahydropyran-2-yloxy)propyl]-6-(3-trifluoromethylphenyl)pyrazolo[3,4-b]pyridine

Participants

Role	Name	HCID	Charge
Reactant	2-(3-Bromopropoxy)tetrahydro-2H-pyran	HCID 2777988	—
Reactant	5-[2-(methylsulfanyl)pyrimidin-4-yl]-6-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine	HCID 67013869	—
Product	5-(2-Methylsulfanylpyrimidin-4-yl)-2-[3-(tetrahydropyran-2-yloxy)propyl]-6-(3-trifluoromethylphenyl)pyrazolo[3,4-b]pyridine	HCID 67014547	—

Reaction Steps

Following a similar procedure to that described in examples 6 and 7, but starting from 5-[2-(methylsulfanyl)pyrimidin-4-yl]-6-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine (obtained in example 126) and 2-(3-bromopropoxy)tetrahydropyran, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07468376B2
Source dataset	uspto-grants-2008_12
ORD ID	ord-970a559e0c854569a453ac2643714143
Source note	uspto-grants-2008_12