1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → N-[2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]ethyl]-1-(tert-butoxycarbonyl)piperidine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid	HCID 392871	—
Reactant	2-(2-Aminoethyl)-4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine	HCID 67013573	—
Product	N-[2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]ethyl]-1-(tert-butoxycarbonyl)piperidine-4-carboxamide	HCID 68443387	—

Reaction Steps

Following a similar procedure to that described in example 48, but starting from 2-(2-aminoethyl)-4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridine (obtained in example 90) and 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid, the desired compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07468376B2
Source dataset	uspto-grants-2008_12
ORD ID	ord-9871b4abd4c4472e9cbe5c49fb5d8bda
Source note	uspto-grants-2008_12