HCID 21949386, compound → 2-(4-Piperidyl)-2-propanol

Benzyl 4-(1-hydroxy-1-methylethyl)piperidine-1-carboxylate (1.786 g, 6.44 mmol) synthesized in Production example 42-2 was dissolved in methanol (100 ml) under nitrogen atmosphere; 10% palladium on carbon (50% wet, 1.37 g) was added; the reaction system was purged with hydrogen at atmospheric pressure; and the reaction mixture was stirred overnight. After the reaction system was purged with nitrogen, the catalyst was filtered out, and washed with methanol; the solvent, together with the filtrate and the washing solution, was distilled off; and the residue was dried under reduced pressure to yield the title compound (922 mg, 6.44 mmol, quantitative) as pale gray crystals.

1. customthe reaction system was purged with hydrogen at atmospheric pressure
2. customAfter the reaction system was purged with nitrogen
3. filtrationthe catalyst was filtered out
4. washwashed with methanol
5. distillationthe solvent, together with the filtrate and the washing solution, was distilled off
6. customand the residue was dried under reduced pressure

ORD record

ord-6ed4f89146664f3fa2990af8a81ff44b

Source dataset

uspto-grants-2008_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07468380B2