HCID 69329080, compound → 2-(Dimethylamino)-1-(piperazin-1-yl)ethan-1-one

HRID 2376852Notes

Reaction equation

HRID 2376852 reaction equation
[CH3:1][N:2]([CH3:23])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][N:9](NC(OCC2C=CC=CC=2)=O)[CH2:8][CH2:7]1)=[O:5]>CO.[Pd]>[CH3:1][N:2]([CH3:23])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5]

Participants

4

Reactant 1

HCID 69329080HCID 69329080, compound

Product 1

HCID 167703022-(Dimethylamino)-1-(piperazin-1-yl)ethan-1-oneYield 95.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl 4-(2-dimethyaminoacetyl)piperazine-1-carbamate (954 mg, 3.12 mmol) synthesized in Production example 51-1 was dissolved in methanol (50 ml) under nitrogen atmosphere; 10% palladium on carbon (50% wet, 665 mg) was added thereto; the reaction system was purged with hydrogen at atmospheric pressure; and the reaction mixture was stirred overnight. After the reaction system was purged with nitrogen, the catalyst was filtered out, and washed with methanol. The solvent, together with the filtrate and washing solution, was distilled off, and the residue was dried under reduced pressure to yield the title compound (508 mg, 2.97 mmol, 95.0%) as a colorless oil.

Workup

  1. customthe reaction system was purged with hydrogen at atmospheric pressure
  2. customAfter the reaction system was purged with nitrogen
  3. filtrationthe catalyst was filtered out
  4. washwashed with methanol
  5. washThe solvent, together with the filtrate and washing solution
  6. distillationwas distilled off
  7. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-81414a04192040d79d4239767b138274
Source dataset
uspto-grants-2008_12
Patent number
US07468380B2

Reaction notes

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