HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 21949177, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | N,N-Diethyl-1,3-propanediamine | HCID 61011 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 21949172 | HCID 21949172 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21949177 | HCID 21949177 | 49.6% |
Reaction Steps
Phenyl N-(4-(3-chloro-1-(methylamino)carbonyl-1H-5-indolyl)oxy-2-pyridyl)carbamate (160 mg), 3-(diethylamino)propylamine (120 mg), N,N-dimethylformamide (5 ml) were mixed together and stirred at room temperature for 10 minutes. After the addition of aqueous sodium hydrogencarbonate, extraction was performed with ethyl acetate. The purification by silica gel column chromatography (Fuji Silysia NH, ethyl acetate and sequentially ethyl acetate:methanol=10:1) to yield the title compound as a white solid (86 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468380B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-edfed077aaaf4870b9a805a6d2c558ac |
| Source note | uspto-grants-2008_12 |