HCID 21949207, compound → 1-(3-Amino-propyl)-piperidin-4-ol

HRID 2376886Notes

Reaction equation

HRID 2376886 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][NH:11]C(=O)OCC2C=CC=CC=2)[CH2:4][CH2:3]1>[C].[Pd].C(O)C>[NH2:11][CH2:10][CH2:9][CH2:8][N:5]1[CH2:4][CH2:3][CH:2]([OH:1])[CH2:7][CH2:6]1

Participants

4

Reactant 1

HCID 21949207HCID 21949207, compound

Product 1

HCID 47124681-(3-Amino-propyl)-piperidin-4-olYield 93.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Ethanol (200 ml) and palladium carbon (2.5 g) were added to benzyl N-(3-(4-hydroxypiperidino)propyl)carbamate (2.96 g); and the reaction mixture was stirred vigorously under hydrogen atmosphere overnight. Palladium carbon was removed by filtration, and the filtrate was concentrated to yield the title compound (1.5 g).

Workup

  1. customPalladium carbon was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-df9187c8eece493d86ba477e99902dc7
Source dataset
uspto-grants-2008_12
Patent number
US07468380B2

Reaction notes

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