o-Fluorobenzaldehyde → 1-fluoro-2-{(E)-2-[4-(phenylsulfonyl)phenyl]vinyl}benzene

HRID 2376968Notes

Reaction equation

HRID 2376968 reaction equation
COP([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1)(=O)OC.[F:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH:26]=O>>[F:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1/[CH:26]=[CH:7]/[C:8]1[CH:13]=[CH:12][C:11]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 67970o-FluorobenzaldehydeHCID 15247537Dimethyl[4-(phenylsulfonyl)benzyl]phosphonate

Product 1

HCID 210994011-fluoro-2-{(E)-2-[4-(phenylsulfonyl)phenyl]vinyl}benzene

Procedure

The title compound was prepared from dimethyl[4-(phenylsulfonyl)benzyl]phosphonate (Step 2) and 2-fluorobenzaldehyde according to the method of Example 46 Step 5. δH (500 MHz, CDCl3): 7.97-7.92 (4H, m), 7.63-7.55 (4H, m), 7.52-7.49 (2H, m), 7.35 (1H, d, J=16.5 Hz), 7.30-7.25 (1H, m), 7.18-7.14 (2H, m), 7.10-7.06 (1H, m).

Sources & evidence

ORD record
ord-ddc9fe8f39b74ac882ee9a2e97e736fe
Source dataset
uspto-grants-2008_12
Patent number
US07468393B2

Reaction notes

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