HRID2376997

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：C[Si](C)(C)CCOCn1ccnc1-c1ccccc1Br

HCID10043629

未命名化合物

反应SMILES：O=S(=O)(c1ccccc1)c1ccc(CCc2ccc(F)cc2F)cc1

HCID21099424

未命名化合物

PRODUCTS

产物

反应SMILES：C[Si](C)(C)CCOCn1ccnc1-c1ccccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2F)cc1

HCID21099411

未命名化合物

PROCEDURE

实验过程

2-[2-({4-[(E)-2-(2,4-Difluorophenyl)vinyl]phenyl}sulfonyl)phenyl]-1-([2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole was prepared according to the method of Example 135 Step 2 using 2-(2-bromophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole (Step 1) in place of (S)-1-(2-iodophenyl)ethanol and Intermediate 2 in place of Intermediate 1.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-1f04502311b841cab8e2d5ef05dd6295
来源数据集: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07468393B2
来源说明: uspto-grants-2008_12

反应SMILES

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH:10]=[CH:11][N:12]=1.[F:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][C:34]([S:37](C2C=CC=CC=2)(=[O:39])=[O:38])=[CH:33][CH:32]=1>>[F:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1/[CH:29]=[CH:30]/[C:31]1[CH:36]=[CH:35][C:34]([S:37]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8]2[N:9]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH:10]=[CH:11][N:12]=2)(=[O:39])=[O:38])=[CH:33][CH:32]=1