N-methyl-2-pyrrolidone → HCID 21099439, compound

Participants

Reaction Steps

2-Fluorobenzenesulfonamide was reacted with 4-bromothiophenol according to the method of Example 46 Step 1 using 1-methyl-2-pyrrolidinone as solvent. The resulting thioether was oxidised to the corresponding sulfoxide by the procedure of Example 16 Step 1. This was coupled with 4-fluorostyrene by the procedure of Example 107 to give the title compound. δH (500 MHz, d6 DMSO): 8.10 (1H, d, J=7.8 Hz), 7.91 (1H, d, J=7.7 Hz), 7.87 (2H, s), 7.81 (1H, t, J=7.4 Hz), 7.71-7.63 (7H, m), 7.31 (1H, d, J=16.5 Hz), 7.22-7.18 (3H, m).

Provenance & Evidence