trans-2-(4-Fluorophenyl)vinylboronic acid → HCID 21099438, compound

HRID 2377012Notes

Reaction equation

HRID 2377012 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13]([NH2:15])=[O:14])(=[O:10])=[O:9])=[CH:4][C:3]=1[CH3:20].[F:21][C:22]1[CH:27]=[CH:26][C:25](/[CH:28]=[CH:29]/B(O)O)=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:27]=[CH:26][C:25](/[CH:28]=[CH:29]/[C:2]2[CH:7]=[CH:6][C:5]([S:8]([C:11]3[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=3[C:13]([NH2:15])=[O:14])(=[O:10])=[O:9])=[CH:4][C:3]=2[CH3:20])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 5706776trans-2-(4-Fluorophenyl)vinylboronic acidHCID 210994192-[(4-Bromo-3-methylphenyl)sulfonyl]benzamide

Product 1

HCID 21099438HCID 21099438, compound

Procedure

The title compound was prepared from 2-[(4-bromo-3-methylphenyl)sulfonyl]benzamide (Step 1) and [(E)-2-(4-fluorophenyl)vinyl]boronic acid according to the method of Example 1 Step 4. m/z (ES+) 379 [(M-NH2)+].

Sources & evidence

ORD record
ord-e382cb7a0c4948c1bb892da36046d1a2
Source dataset
uspto-grants-2008_12
Patent number
US07468393B2

Reaction notes

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