Water → HCID 21099510, compound

Participants

Reaction Steps

A solution of acetohydroxamic acid (75 mg, 1 mmol) in N,N-dimethylformamide was treated at room temperature with potassium tert-butoxide and stirred for 30 minutes. 2-fluoro-6-({4-[(E)-2-(4-fluorophenyl)vinyl]phenyl}sulfonyl)benzonitrile (Example 112, 100 mg, 0.26 mmol) was added and the reaction stirred for 5 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with brine (×5), dried over MgSO4 and evaporated. The residue was purified by flash column chromatography on silica to give the title compound (30 mg, 29%).

Provenance & Evidence