Hydrochloric Acid → HCID 86610911, compound

Participants

Reaction Steps

To a solution of 1.5 g (2.876 mmol) tert-butyl (3R,4S)-3-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}oxy)-4-(4-fluorophenyl)pyrrolidine-1-carboxylate (Step C) in 10 mL EtOAc was added 10 mL of a solution of sat. anhdr. HCl in EtOAc. The reaction mixture was a stirred at RT for 24 hr and the solvent removed under vacuum to afford a yellow oil. The resulting oil was recrystallized from ether/hexanes (3/7) to afford the title compound as a white solid (mp=107° C.). 1H-NMR (CD3OD): δ: 1.43 (d, 3H, 6.5 Hz), 3.27 (t, 1H, 8.5 Hz), 3.44 (m, 2H), 3.73 (m, 2H), 4.20 (q, 1H, 5.5 Hz), 4.78 (q, 1H, 6.5 Hz), 7.01 (t, 2H), 7.20 (dd, 2H), 7.73 (s, 2H), 7.82 (s, 1H)ppm. MS: 422.1 (MH)+ observed.

Provenance & Evidence