Methyl iodide → HCID 86610914, compound

Participants

Reaction Conditions

Reaction Steps

In a pressure tube, 22 mg (0.0394 mmol) 3-[(3R,4S)-3-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}oxy)-4-(4-fluorophenyl)pyrrolidin-1-yl]-2-[(dimethylamino)methyl]cyclopent-2-en-1-one (step A), and 0.025 mL (0.3939 mmol) iodomethane was dissolved in benzene (1 mL). The tube was sealed and heated in an oil bath for 2.5 hr at ˜60° C. The reaction mixture was cooled to RT, the tube was opened and the solvent removed under vacuum to afford the title compound as a yellow oil which was used in the next reaction without further purification.

Provenance & Evidence