Methanol → Methyl (6S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylate--hydrogen chloride (1/2)
Reaction equation
S(Cl)([Cl:3])=O.[ClH:5].Cl.[N:7]1[C:15]2[CH2:14][C@@H:13]([C:16]([OH:18])=[O:17])[NH:12][CH2:11][C:10]=2[NH:9][CH:8]=1.[CH3:19]O>>[ClH:3].[ClH:5].[N:7]1[C:15]2[CH2:14][C@@H:13]([C:16]([O:18][CH3:19])=[O:17])[NH:12][CH2:11][C:10]=2[NH:9][CH:8]=1Participants
Procedure
Thionylchloride (200 mL, 2.74 mol, 3.0 mol eqv.) was added dropwise to methanol (3.5 L), which was cooled to 0-5° C. (6S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride (210.0 g, 0.87 mol) was added The suspension was allowed to warm up to room temperature, and refluxed for 3.5 h. After cooling to room temperature, the solvent was removed under reduced pressure. The white residue was suspended in ether (3 L). The solid was filtered and washed with ether. After drying in a vacuum oven (40° C.), the title compound was obtained (225.0 g, 100% yield, 95% pure). 1H NMR (DMSO-d6): δ ppm 12.65 (br s, 2H), 9.04 (s, 1H), 4.71 (m, 1H), 4.33 (t, J=16.2 Hz, 2H), 3.81 (s, 3H), 3.10-3.33 (m, 2H), LCMS: Rt=0.61 min and M+1=182.1 u/e (M+1 of free base).
Workup
- additionwas added The suspension
- temperaturerefluxed for 3.5 h
- temperatureAfter cooling to room temperature
- customthe solvent was removed under reduced pressure
- filtrationThe solid was filtered
- washwashed with ether
- customAfter drying in a vacuum oven (40° C.)
Sources & evidence
- ORD record
- ord-c218b6a312d24ddf8dd48e40e579b42c
- Source dataset
- uspto-grants-2008_12
- Patent number
- US07468375B2
Reaction notes
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