反应详情

The title compound was prepared by coupling of 1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid with N-isopropyl hydroxylamine hydrochloride in a manner similar to step 8 of example 1. 1H NMR (CDCl3) δ ppm 8.59 (s, 1H), 8.46 (s, 1H), 7.39 (s, 1H), 7.10 (m, 2H), 7.02 (d, 2H, J=8.6 Hz), 6.73 (s, 1H), 5.41 (s, 2H), 5.08 (m, 1H), 1.33 (d, 6H, J=6.6 Hz). LCMS (APCI, M+H+): 328.1 HRMS calcd for C18H18FN3O2 (M+H) 328.1456, found 328.1456. HPLC: 95.8% purity.