反应详情

The title compound was prepared by coupling of 1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid with N-propyl hydroxylamine hydrochloride in a manner similar to step 8 of example 1. 1H NMR (DMSO-d6) δ ppm 11.93 (br s, 1H), 8.88 (s, 1H), 7.99 (s, 1H), 7.88 (d, 1H, J=3.0 Hz), 7.34 (m, 2H), 7.15 (d, 2H, J=8.8 Hz), 6.69 (d, 1H, J=3.0 Hz), 5.56 (s, 2H), 3.66 (t, 2H, J=7.1 Hz), 1.64 (m, 2H), 0.83 (s, 3H). LCMS (API-ES, M+H+): 328.1. HRMS calcd for C18H19FN3O2 (M+H) 328.1456, found 328.1458. HPLC: 100% purity.