1-Iodo-3-methylbutane → HCID 44549916, compound

HRID 2377063Notes

Reaction equation

HRID 2377063 reaction equation
[Na].[CH3:2][C:3]1[NH:4][O:5][C:6](=[O:13])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].IC[CH2:16][CH:17]([CH3:19])[CH3:18]>>[CH3:2][C:3]1[N:4]([CH2:16][CH:17]([CH3:19])[CH3:18])[O:5][C:6](=[O:13])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 109241-Iodo-3-methylbutaneHCID 69198820HCID 69198820, compound

Product 1

HCID 44549916HCID 44549916, compound

Procedure

The title compound was prepared by alkylation of ethyl 3-methyl-5-oxo-2,5-dihydroisoxazole-4-carboxylate sodium salt with 1-iodo-3-methylbutane in a manner similar to step 1 of example 28. 1H NMR (CDCl3) δ ppm 4.12 (q, 2H, J=7.1 Hz), 3.47 (t, 2H, J=6.8 Hz), 2.35 (s, 3H), 1.97-2.07 (m, 1H), 1.16 (t, 3H, J=7.0 Hz), 0.77 (d, 6H, J=6.8 Hz). LCMS (APCI, M+H+): 228.2.

Sources & evidence

ORD record
ord-080dc74649374bd5b52ec85483bb94b3
Source dataset
uspto-grants-2008_12
Patent number
US07468375B2

Reaction notes

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