Hydrochloric Acid → HCID 86697376, compound

Participants

Reaction Steps

1 M Aqueous NaOH solution (70 μL) is added to a solution of methyl 2-((S)-6-((R)-4-(4-(3-(dimethylamino)-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate (20 mg) in methanol (2 mL) at room temperature. The mixture is stirred at room temperature for 48 hours, treated with 1 M aqueous NaOH solution (70 μL) and heated for 4 hours at 50° C. The mixture is neutralized by addition of 1 N aqueous HCl solution and purified by HPLC on reversed phase to give the title compound. Yield: 11 mg; LC (method 14): tR=0.95 min; Mass spectrum (ESI+): m/z=562 [M+H]+.

Provenance & Evidence