O-Methylhydroxylamine hydrochloride → HCID 11718913, compound

Participants

Reaction Steps

The title compound was prepared by coupling of 1-(2,4-difluorobenzyl)-3-[(4-methylpiperazin-1-yl)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid and O-methylhydroxylamine hydrochloride in analogy to step 2 of example 17. 1H NMR (MeOH-d4) δ 8.77 (s, 1H), 8.43 (s, 1H), 7.59 (s, 1H), 7.27-7.03 (m, 1H) 7.01-6.93 (m, 2H), 5.55 (s, 2H), 3.82 (s, 5H), 2.82 (m, 4H), 2.66 (m, 4H), 2.50 (s, 3H). LCMS (APCI, M+H+): 430.2. Anal. (C22H22F2N5O3×1.5H2O×0.8AcOH)C, H, N.

Provenance & Evidence