反应详情

To a solution of 4-ethynyl-1-(4-fluoro-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (60 mg, 0.018 mmol, prepared in step 1 above) in EtOH (2 mL) was added Lindlar's catalyst (Aldrich, 20 mg). The atmosphere was vacuum degassed with hydrogen three times, and then a balloon of hydrogen was attached to the reaction. After stirring for 18 hours, the reaction was filtered through a fine filter to remove the palladium. The solvent was removed by rotary evaporation, and the crude oil was carried on without further purification. Yield 57 mg, 94%. MS (APCI): Calc: 326, Found: (M+H) 327.

1. customdegassed with hydrogen three times
2. customa balloon of hydrogen was attached to the reaction
3. filtrationthe reaction was filtered through
4. filtrationa fine filter
5. customto remove the palladium
6. customThe solvent was removed by rotary evaporation
7. customthe crude oil was carried on without further purification