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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2377114Generated: November 4, 2026

1-Phenylethanol, (R)- → 1h-Pyrrolo[2,3-c]pyridine-5-carboxylic acid,1-[(4-fluorophenyl)methyl]-3-[[(1r)-1-phenylethoxy]methyl]-,methyl ester

https://huagongshe.com/reaction/2377114

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Phenylethanol, (R)-HCID 637516—
ReactantHCID 59855831HCID 59855831—
Product1h-Pyrrolo[2,3-c]pyridine-5-carboxylic acid,1-[(4-fluorophenyl)methyl]-3-[[(1r)-1-phenylethoxy]methyl]-,methyl esterHCID 59855835—

Reaction Steps

The title compound was prepared as in example 116, step 1, using methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate and (1R)-1-phenylethanol. 1H NMR (300 MHz, CHLOROFORM-D) δ ppm 1.48 (d, J=6.41 Hz, 3H) 4.01 (s, 3H) 4.48-4.59 (m, 3H) 5.34 (s, 2H) 6.97-7.05 (m, 2H) 7.10-7.17 (m, 2H) 7.23 (s, 1H) 7.29-7.42 (m, 5H) 8.47 (s, 1H) 8.72 (s, 1H)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07468375B2
Source datasetuspto-grants-2008_12
ORD IDord-616139b272844edf996beff6f4816b8e
Source noteuspto-grants-2008_12