反应详情

To a stirred solution of benzofuran-5-yl-(3-ethoxy-4-methoxy-phenyl)-methanol (2.36 g crude, 6.8 mmol) in CH2Cl2 (15 mL) at room temperature was added activated MnO2 powder (6.0 g, 69 mmol) and kept adding 2˜3 equivalents of MnO2 every 3˜5 h until HPLC showed disappearance of the starting material. The black suspension was filtered through a Celite pad, concentrated in vacuo to give benzofuran-5-yl-(3-ethoxy-4-methoxy-phenyl)-methanone as an off-white solid (2.25 g, 111% crude yield). The product was used in the next step without further purification.

1. filtrationThe black suspension was filtered through a Celite pad
2. concentrationconcentrated in vacuo