Sodium Hydroxide → HCID 71737974, compound

Participants

Reaction Steps

1 M aqueous NaOH solution (250 μL) is added to a solution of methyl 2-((S)-6-((R)-7-fluoro-4-(4-((1,1-dioxo-4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate (85 mg) in tetrahydrofurane (4 mL). The mixture is stirred at room temperature for 12 hours. Then the mixture is diluted with ethyl acetate and neutralized with 1 M aqueous HCl solution. The resulting mixture is diluted with saturated aqueous NaCl solution and the phases are separated. The organic phase is dried (MgSO4) and concentrated to give the title compound. Yield: 80 mg; LC (method 7): tR=1.04 min; Mass spectrum (ESI+): m/z=611 [M+H]+.

Provenance & Evidence