反应详情

970 mg (2.6 mmol) of 1-(6-benzyloxy-5-tert-butyl-4′-methyl-3-biphenylyl)ethanone are dissolved in 40 mL of methanol. 350 mg (2.3 mmol) of 4-carboxybenzaldehyde are added, followed by 1.23 mL (10 mmol) of 47% KOH. The reaction medium is stirred for 36 hours and then acidified with concentrated hydrochloric acid. The medium is extracted with ethyl acetate, and the residue obtained is purified by chromatography on a column of silica. The solid obtained is recrystallized from an ethyl ether/heptane mixture. A yellow powder is obtained (m=500 mg; yield=38%; m.p.=208° C.).

1. extractionThe medium is extracted with ethyl acetate
2. customthe residue obtained
3. customis purified by chromatography on a column of silica
4. customThe solid obtained
5. customis recrystallized from an ethyl ether/heptane mixture
6. customA yellow powder is obtained (m=500 mg; yield=38%; m.p.=208° C.)