Potassium Carbonate → HCID 86598699, compound

Participants

Reaction Conditions

Reaction Steps

1.4 g (3.8 mmol) of 3-formyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-1-naphthyl 1,1,1-trifluoromethanesulfonate are dissolved in 50 mL of DME, followed by 625 mg (4.6 mmol) of p-tolylboronic acid. 485 mg (11.4 mmol) of lithium chloride and 4.6 mL (9.2 mmol) of 2 M potassium carbonate solution are added to the reaction medium, which is then degassed with a flow of nitrogen and then heated to 90° C. 220 mg of tetrakis(triphenylphosphine)palladium are added and the reaction medium is stirred at reflux for 20 hours, then hydrolysed and extracted with ethyl acetate. The residue obtained is purified by chromatography, to give an orange-colored oil (m=980 mg; yield=85%).

Provenance & Evidence