HCID 86598699, compound → HCID 86598701, compound

HRID 2377208Notes

Reaction equation

HRID 2377208 reaction equation
[CH3:1][C:2]1([CH3:23])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH:14]=[O:15])[CH:5]=[C:4]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)[C:3]1=2.[C:24]([Mg]Br)#[CH:25]>>[CH3:1][C:2]1([CH3:23])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([CH:14]([OH:15])[C:24]#[CH:25])[CH:5]=[C:4]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)[C:3]1=2

Participants

3

Reactant 2

HCID 86598699HCID 86598699, compoundHCID 178418486HCID 178418486, compound

Product 1

HCID 86598701HCID 86598701, compoundYield 98%

Procedure

In a similar manner to that of Example 1 f, by reacting 950 mg (3.1 mmol) of 5,5,8,8-tetramethyl-4-p-tolyl-5,6,7,8-tetrahydro-2-naphthalenecarbaldehyde with 4.5 mL (4.5 mmol) of 1 N ethynylmagnesium bromide solution. A colorless oil is obtained (m=1 g; yield=98%).

Workup

  1. customA colorless oil is obtained (m=1 g; yield=98%)

Sources & evidence

ORD record
ord-f91dcf40d1db4e6fbc2fc4284e329cda
Source dataset
uspto-grants-2008_12
Patent number
US07468457B2

Reaction notes

Loading…