4-Iodobenzoic acid → HCID 10389172, compound

Participants

Reaction Steps

In a similar manner to that of Example 1g, by reacting 950 mg (2.9 mmol) of 1-(5,5,8,8-tetramethyl-4-p-tolyl-5,6,7,8-tetrahydro-2-naphthyl)prop-2-yn-1-ol with 595 mg (2.4 mmol) of 4-iodobenzoic acid in the presence of 47 mg of copper iodide and 54 mg of bis(triphenylphosphine)dichloropalladium. The desired product is obtained in the form of white crystals (m=1 g; yield=81%; m.p.=207° C.).

Provenance & Evidence