4-Formylbenzoic acid → HCID 12084827, compound

HRID 2377213Notes

Reaction equation

HRID 2377213 reaction equation
[CH3:1][C:2]1([CH3:24])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14](=[O:16])[CH3:15])[CH:5]=[C:4]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[C:3]1=2.[C:25]([C:28]1[CH:35]=[CH:34][C:31]([CH:32]=O)=[CH:30][CH:29]=1)([OH:27])=[O:26].[OH-].[K+]>>[O:16]=[C:14]([C:6]1[CH:5]=[C:4]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)[C:3]2[C:2]([CH3:24])([CH3:1])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]=2[CH:7]=1)/[CH:15]=[CH:32]/[C:31]1[CH:34]=[CH:35][C:28]([C:25]([OH:27])=[O:26])=[CH:29][CH:30]=1

Participants

4

Reactant 3

HCID 120884-Formylbenzoic acidHCID 14797Potassium HydroxideHCID 67020685HCID 67020685, compound

Product 1

HCID 12084827HCID 12084827, compoundYield 72%

Procedure

In a similar manner to that of Example 2b, by reacting 770 mg (2.4 mmol) of 1-(5,5,8,8-tetramethyl-4-p-tolyl-5,6,7,8-tetrahydro-2-naphthyl)ethanone with 320 mg (2.2 mmol) of 4-carboxybenzaldehyde and 1.2 mL (10 mmol) of 47% KOH. The desired product is obtained in the form of white crystals (m=780 mg; yield=72%; m.p.=242° C.).

Sources & evidence

ORD record
ord-87a91f83b6ea4af28be92614b08dc6ca
Source dataset
uspto-grants-2008_12
Patent number
US07468457B2

Reaction notes

Loading…