4-Formylbenzoic acid → HCID 66671956, compound

HRID 2377215Notes

Reaction equation

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[C:19]([CH3:22])([CH3:21])[CH2:18][CH2:17][C:16]([CH3:24])([CH3:23])[C:15]=3[CH:14]=[C:13]([C:25](=[O:27])[CH3:26])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:28]([C:31]1[CH:38]=[CH:37][C:34]([CH:35]=O)=[CH:33][CH:32]=1)([OH:30])=[O:29].[OH-].[K+]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:20]3[C:19]([CH3:22])([CH3:21])[CH2:18][CH2:17][C:16]([CH3:24])([CH3:23])[C:15]=3[CH:14]=[C:13]([C:25](=[O:27])/[CH:26]=[CH:35]/[C:34]3[CH:37]=[CH:38][C:31]([C:28]([OH:30])=[O:29])=[CH:32][CH:33]=3)[CH:12]=2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 3

HCID 120884-Formylbenzoic acid

HCID 14797Potassium Hydroxide

HCID 67020708HCID 67020708, compound

Product 1

HCID 66671956HCID 66671956, compoundYield 61%

Procedure

In a manner similar to that of Example 2b, by reacting 710 mg (2.0 mmol) of 1-[4-(4-tert-butylphenyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl]ethanone with 260 mg (1.8 mmol) of 4-carboxybenzaldehyde and 1.0 mL (8 mmol) of 47% KOH. The desired product is obtained in the form of white crystals (m=590 mg; yield=61%; m.p.=241° C.).

Sources & evidence

ORD record: ord-1420dfc874b64696a12cbd092d975ad1
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07468457B2

Reaction notes

Loading…