2-((S)-6-((R)-4-(4-(2,5-Dihydrofuran-3-yl)-2,6-dimethylphenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid → 2-((3S)-6-((1R)-4-(2,6-Dimethyl-4-(tetrahydrofuran-3-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

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Reaction Steps

The title compound is prepared from 2-((S)-6-((R)-4-(4-(2,5-dihydrofuran-3-yl)-2,6-dimethylphenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid by hydrogenation in the presence of palladium (10% on carbon) in ethyl acetate at room temperature. LC (method 9): tR=1.17 min; Mass spectrum (ESI+): m/z=503 [M+H]+.

Provenance & Evidence