Glycine tert-butyl ester → HCID 69203341, compound

Participants

Reaction Steps

To a solution of Example 6 (250 mg, 0.98 mmol) in N,N-dimethylformamide (5 mL) was added N-cyclohexylcarbodiimide-N′-methyl polystyrene (761 mg, 1.5 mmol) and 1-hydroxybenzotriazole hydrate (255 mg, 1.7 mmol). The mixture was agitated at room temperature for about 5 minutes, treated with t-butyl glycinate (150 mg, 1.2 mmol), shaken for about 15 hours, and filtered. The filtrate was concentrated under vacuum and the residue was purified by flash column chromatography on silica gel using hexane/ethyl acetate (1:1) as the moblie phase to provide the desired product. MS (APCI): m/z 311, 313 (M+H-tBu)+.

Provenance & Evidence