1,4-Oxazepane → {(S)-6-[(R)-7-Fluoro-4-(2-[1,4]oxazepan-4-yl-pyridin-3-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

HRID 237726Notes

Reaction equation

HRID 237726 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([C:25]5[C:26](F)=[N:27][CH:28]=[CH:29][CH:30]=5)[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[O:33]1[CH2:39][CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[F:24][C:22]1[CH:21]=[CH:20][C:19]([C:25]2[C:26]([N:36]3[CH2:37][CH2:38][CH2:39][O:33][CH2:34][CH2:35]3)=[N:27][CH:28]=[CH:29][CH:30]=2)=[C:18]2[C:23]=1[C@H:15]([O:14][C:12]1[CH:11]=[CH:10][C:9]3[C@H:5]([CH2:4][C:3]([OH:2])=[O:32])[CH2:6][O:7][C:8]=3[CH:13]=1)[CH2:16][CH2:17]2

Participants

3

Reactant 2

HCID 218732751,4-OxazepaneHCID 86697397{(S)-6-[(R)-7-fluoro-4-(2-fluoro-pyridin-3-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Product 1

HCID 86697396{(S)-6-[(R)-7-Fluoro-4-(2-[1,4]oxazepan-4-yl-pyridin-3-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

Procedure

The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-(2-fluoro-pyridin-3-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and [1,4]oxazepane following a procedure analogous to that described for Example 128. LC (method 9): tR=0.87 min; Mass spectrum (ESI+): m/z=505 [M+H]+.

Sources & evidence

ORD record
ord-a2f3900ba263496784981553d7115e42
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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