HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 69202369, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-{1-[Bis(4-methoxyphenyl)methyl]-6-[(4-methyl-1-piperazinyl)methyl]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl}-2-thiophenecarbaldehyde | HCID 87732437 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69202369 | HCID 69202369 | — |
Reaction Steps
To a solution of Example 331 (8.5 g, 14.1 mmol) in methanol (150 mL) and tetrahydrofuran (80 mL) was added sodium borohydride (530 mg, 14.1 mmol) at about 0° C. The mixture was stirred for about 3 hours while being allowed to warm to room temperature and was then concentrated under vacuum. The residue was diluted with water, extracted with ethyl acetate and the combined organic extracts were dried (MgSO4), filtered, and concentrated. The residue was purified by flash chromatography on silica gel using dichloromethane/methanol (10:1) as eluent to provide the desired product. MS (ESI): m/z 607 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468371B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-540ab2b8dfe646da8233d52df25f8386 |
| Source note | uspto-grants-2008_12 |