Aniline → HCID 13765089, compound

HRID 2377280Notes

Reaction equation

HRID 2377280 reaction equation
BrC1C=C2[C:5]([CH2:6][CH2:7][C:8]2=[O:11])=[C:4](C(O)=O)C=1.[NH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.NCC(OC(C)(C)C)=O>>[C:16]1([NH:15][C:8](=[O:11])[CH2:7][CH2:6][C:5]#[CH:4])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 151417Glycine tert-butyl esterHCID 692008516-Bromo-1-oxo-2,3-dihydro-1H-indene-4-carboxylic acid

Product 1

HCID 13765089HCID 13765089, compound

Procedure

The procedure for Example 41 was used, substituting 4-pentynoic acid for 6-bromo-4-carboxy-1-indanone and aniline for t-butyl glycinate to provide Example 645. MS (ESI): m/z 174 (M+H)+.

Workup

  1. customto provide Example 645

Sources & evidence

ORD record
ord-d470994854fe4bb48afa38a7265abaee
Source dataset
uspto-grants-2008_12
Patent number
US07468371B2

Reaction notes

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