1,1'-Carbonyldiimidazole → HCID 69202402, compound

Participants

Reaction Steps

To a solution of Example 891D (800 mg, 1.62 mmol) in THF (15 mL) was added 1,1′-carbonyldiimidazole (320 mg, 1.94 mmol). The mixture was stirred at rt for 2 h, then a solution of 4-(2-aminoethyl)morpholine (253 mg, 1.94 mmol) in THF (3 mL) was added. The resulting mixture was stirred at rt for 6 h, then concentrated in vacuo. The residue was purified by flash chromatography eluting with EtOAc to give a crude oil. (326 mg).

Provenance & Evidence