Water → Tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

Tert-butyl piperazine-1-carboxylate (5.3 g, 28.5 mmol) and triethylamine (6 mL) were combined in dichloromethane (60 mL) and treated with methanesulfonyl chloride (2.6 mL, 33.6 mmol) at about 0° C. The mixture was stirred at about 0° C. for about 30 min, water (100 mL) was added and the mixture was extracted with dichloromethane. The combined organic layers were dried over MgSO4, filtered and concentrated under vacuum to provide the desired product. 1H NMR (300 MHz, CDCL3): δ 1.42 (s, 9H), 2.80 (s, 3H), 3.18 (t, J=7.0 Hz, 4H), 3.56 (t, J=7.0 Hz, 4H).

Provenance & Evidence